Smoking is an addictive, chronic and relapsing disease. This is the main cause of preventable death in the occidental world and responsible to multiples diseases. However, this is a disease that we can treat and cure. Currently, there are some tools available to help smokers to stop smoking e.g psychological therapy and new methods like the use of mobile Apps. Virgen del Rocío University Hospital takes part SmokeFreeBrain which aims to develop an intervention based on the use of mobile Apps.